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Hematoxylin and eosin LH, luteinizing hormone PAF, preantral follicle PCO(S), The disorder is oftenīiochemically present soon after menarche or even at the time ofĪbbreviations: AF, antral follicle CF, cystic follicle CL, corpora lutea FFPE,įormalin fixed paraffin embedded FSH, follicle-stimulating hormone HE, Insulin resistance, type 2 Diabetes mellitus, cardiovascular diseaseĪnd infertility (Tsilchorozidou et al., 2004). Numerous major metabolic and reproductive disorders such as
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Minor clinical disturbances of the menstrual cycle or it can induce Syndrome exists either as a minimal biochemical disorder with Ovaries with exclusion of other etiologies (Rotterdam ESHRE/ĪSRM-Sponsored PCOS Consensus Workshop Group, 2004). TheĬriteria defining the syndrome include clinical and/or biochemicalĮvidence of hyperandrogenism, oligo-/anovulation and polycystic Occur in 5–10% of women of reproductive age (Aherne, 2004). Polycystic ovary syndrome (PCOS) is the most common cause ofĪnovulation in woman of reproductive age (Dunaif, 1997) and may Gonadotropins and follicular angiogenesis. Stages of folliculogenesis in polycystic ovaries and this may result from crosstalk between circulating Our results provide evidence of intrinsic abnormality during all Reduction in cystic and atretic follicles. Reduced blood vessels of the theca layer was found in all stages of folliculog enesis with a distinct Reduced immunostaining for NOTCH1 and JAGGED1 of Treated animals showed statistically significant lower progesterone and higher testosterone In controls, preantral and antral follicles were larger than in the treated CD31 stained blood vessels in the theca layer were reduced, with reduced JAGGED1Īnd NOTCH1 immunostaining. Large cystic follicles, thick stromal tissue, many atretic preantral follicles, no ovulation and a thinner Were subsequently sacrificed after 21, 28 and 35 days of treatment. Control and treated subgroups (6 rats per subgroup) Controls received the sameĪmount of ricinus oil. TreatedĪnimals received intramuscularly testosteronenantat weekly (0.1 mg/g). The rats were randomly divided into control (n = 18) and treated (n = 18) groups. NOTCH1 and JAGGED1 in induced polycystic ovaries of immature female Wistar rats, as well as serum We analyzed histomorphometrical changes and blood vessel immunohistochemical staining of CD31, In experimentally induced polycystic ovaries of immature ratsĪnita Skrtic a,n, Lea Sokolic b, Ana Borovecki a, Jagoda Rosa c, Vanja Fenzl aĭepartment of Gynaecological Pathology and GY & OB, University Hospital Merkur, Zajceva 19, 10000 Zagreb, Croatiaĭepartment of Laboratory Medicine, University Hospital Vuk Vrhovac, University of Zagreb, Dugi dol 4a, 10000 Zagreb, Croatiaĭepartment of Physiology, School of Dental Medicine, University of Zagreb, Salata 3, 10000 Zagreb, Croatia Journal homepage: Immunohistochemical localization of CD31, NOTCH1 and JAGGED1 proteins Contents lists available at ScienceDirect